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磷酸化T細胞激活核轉錄因子4抗體

產品貨號：

BN41336R
中文名稱：

磷酸化T細胞激活核轉錄因子4抗體
英文名稱：

Rabbit anti-phospho-NFATC4 (Ser168 + Ser170) Polyclonal antibody
品牌：

Biorigin

貨號

產品規(guī)格

售價

備注
BN41336R-100ul

100ul

￥2470.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	phospho-NFATC4 (Ser168 + Ser170)
中文名稱	磷酸化T細胞激活核轉錄因子4抗體
別名	NFATC4 (phospho S168 + S170); p-NFATC4 (phospho S168 + S170); NFATC4 cytoplasmic 4; NF ATc4; NF-AT3; NF-ATc4; NFAC4_HUMAN; NFAT3; NFATc4; Nuclear factor of activated T cells cytoplasmic 4; Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4; Nuclear factor of activated T-cells; nuclear factor of activated T-cells cytoplasmic 4; Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 4; T cell transcription factor NFAT3; T-cell transcription factor NFAT3.
產品類型	磷酸化抗體
研究領域	細胞生物神經生物學 t-淋巴細胞表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse,
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	95kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human NFATC4 around the phosphorylation site of Ser168 + Ser170:FF(p-S)P(p-S)PG
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The product of this gene is a member of the nuclearfactors of activated T cells DNA-binding transcription complex.This complex consists of at least two components: a preexistingcytosolic component that translocates to the nucleus upon T cellreceptor (TCR) stimulation and an inducible nuclear component.Other members of this family of nuclear factors of activated Tcells also participate in the formation of this complex. Theproduct of this gene plays a role in the inducible expression ofcytokine genes in T cells, especially in the induction of the IL-2and IL-4. Alternatively spliced transcript variants encodingdifferent isoforms have been noted for this gene. [provided byRefSeq, Oct 2008]. Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3. Subcellular Location: Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Tissue Specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. Post-translational modifications: Phosphorylated by NFATC-kinases; dephosphorylated bycalcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1,MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and onSer-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B. Similarity: Contains 1 IPT/TIG domain. Contains 1 RHD (Rel-like) domain. Database links : UniProtKB/Swiss-Prot: Q14934.2 SWISS: Q14934 Gene ID: 4776 Database links: Entrez Gene: 4776 Human Entrez Gene: 73181 Mouse Entrez Gene: 305897 Rat Omim: 602699 Human SwissProt: Q14934 Human SwissProt: Q8K120 Mouse Unigene: 77810 Human Unigene: 27908 Mouse Unigene: 23727 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.