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細(xì)胞色素C抗體

產(chǎn)品貨號(hào)：

BN41460R
中文名稱：

細(xì)胞色素C抗體
英文名稱：

Rabbit anti-Cytochrome C Polyclonal antibody
品牌：

Biorigin

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BN41460R-50ul

50ul

￥1486.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:GuineaPig,Rabbit,Horse,Cow,Pig,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41460R-100ul

100ul

￥2360.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:GuineaPig,Rabbit,Horse,Cow,Pig,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41460R-200ul

200ul

￥3490.00

交叉反應(yīng)：Rat,Mouse,Human(predicted:GuineaPig,Rabbit,Horse,Cow,Pig,Chicken) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	Cytochrome C
中文名稱	細(xì)胞色素C抗體
別名	CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome-c; MSA06; THC4.

研究領(lǐng)域	腫瘤心血管細(xì)胞生物神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡脂蛋白新陳代謝線粒體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Mouse, Rat, (predicted: Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	12.8/26kDa
細(xì)胞定位	細(xì)胞漿細(xì)胞膜線粒體
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Cytochrome C:51-105/105
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis. Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Subcellular Location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. Post-translational modifications: Binds 1 heme group per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. DISEASE: Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation. Similarity: Belongs to the cytochrome c family. SWISS: P99999 Gene ID: 54205 Database links: Entrez Gene: 54205 Human Entrez Gene: 13063 Mouse Entrez Gene: 25309 Rat Omim: 123970 Human SwissProt: P99999 Human SwissProt: P62897 Mouse SwissProt: P62898 Rat Unigene: 437060 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞色素C（cytC）是一種電子傳遞鏈蛋白為線粒體呼吸鏈必須的成份之一。在哺乳動(dòng)物細(xì)胞中，如此高度保守性蛋白常分布在線粒體內(nèi)膜。新近研究證明細(xì)胞漿中細(xì)胞色素C為激活細(xì)胞調(diào)亡所必需的因子。在調(diào)亡的過程中，細(xì)胞色素C從線粒體膜被易位到細(xì)胞漿，由細(xì)胞色素C激活Caspase-3（CPP32）。細(xì)胞色素C的易位可被過量表達(dá)的Bcl-2阻斷。細(xì)胞色素B與細(xì)胞色素C1和Rieske蛋白相結(jié)合而形成復(fù)合物III（也稱細(xì)胞色素B-C1復(fù)合物）參與細(xì)胞呼吸鏈。該蛋白動(dòng)物種屬間同源性較高；如：豬、犬、牛、雞、豚鼠等。