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骨形態(tài)發(fā)生蛋白2抗體

產(chǎn)品貨號：

BN41972M
中文名稱：

骨形態(tài)發(fā)生蛋白2抗體
英文名稱：

Mouse anti-BMP2 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN41972M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA
BN41972M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA
BN41972M-200ul

200ul

￥3490.00

交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱	BMP2
中文名稱	骨形態(tài)發(fā)生蛋白2抗體
別名	Bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2A; BMP-2; BMP2_HUMAN.
研究領(lǐng)域	細胞生物免疫學(xué) 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 生長因子和激素
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	7F9
交叉反應(yīng)	Human,
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	13/44kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human BMP2 :
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis. Function: Induces cartilage and bone formation. Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Subcellular Location: Secreted. Tissue Specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. Similarity: Belongs to the TGF-beta family. SWISS: P12643 Gene ID: 650 Database links: Entrez Gene: 650 Human Entrez Gene: 12156 Mouse Entrez Gene: 29373 Rat Omim: 112261 Human SwissProt: P12643 Human SwissProt: P21274 Mouse SwissProt: P49001 Rat Unigene: 73853 Human Unigene: 103205 Mouse Unigene: 90931 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)干細胞標志物 BMP-2主要對未分化間充質(zhì)細胞和骨系細胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細胞向骨形成中心募集，并分化為骨系細胞，而且可使成纖維細胞、成肌細胞及骨髓的基細胞逆轉(zhuǎn)分化為骨系細胞。其主要過程是：增加或抑制這些細胞內(nèi)的某些特異性蛋白的分泌，使成纖維細胞分化為成骨細胞，成肌細胞快速分化為肥大的軟骨細胞，并促進基質(zhì)鈣化。對于成骨細胞，BMP-2則可使之維持其特有細胞表型，并誘導(dǎo)成骨細胞標志物的增高，促進細胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細胞分化因子與其它支持破骨細胞分化因子直接或間接刺激破骨細胞分化，參與骨的重建。