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熱休克蛋白90α單克隆抗體

產(chǎn)品貨號：

BN42020M
中文名稱：

熱休克蛋白90α單克隆抗體
英文名稱：

Mouse anti-HSP90 alpha Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42020M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF
BN42020M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱	HSP90 alpha
中文名稱	熱休克蛋白90α單克隆抗體
別名	HSP-90 alpha; HSP 86; HSP 86; Renal carcinoma antigen NY REN 38; Heat shock 86 kDa; Heat shock 90kDa protein 1 alpha; Heat shock protein 90kDa alpha (cytosolic) class A member 1; heat shock protein 90kDa alpha (cytosolic), class A member 2; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 86; HSP86; Hsp89; HSP89A; HSP90A; HSP90AA1; HSP90ALPHA; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL3; HSPCAL4; HSPN; LAP2; Renal carcinoma antigen NY-REN-38.
研究領(lǐng)域	腫瘤免疫學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	3H7
交叉反應(yīng)	Human, Mouse, (predicted: Rat, )
產(chǎn)品應(yīng)用	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	81kDa
細(xì)胞定位	細(xì)胞漿細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human HSP90 alpha Protein:549-692/732
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Hsp90 (heat shock protein 90) is a molecular chaperone and is one of the most abundant proteins in unstressed cells. It is an ubiquitous molecular chaperone found in eubacteria and all branches of eukarya, but it is apparently absent in archaea. Whereas cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions. Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Subcellular Location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Post-translational modifications: ISGylated. S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1. Similarity: Belongs to the heat shock protein 90 family. SWISS: P07900 Gene ID: 3320 Database links: Entrez Gene: 3320 Human Entrez Gene: 15519 Mouse Entrez Gene: 299331 Rat Omim: 140571 Human SwissProt: P07900 Human SwissProt: P07901 Mouse SwissProt: P82995 Rat Unigene: 525600 Human Unigene: 700831 Human Unigene: 1843 Mouse Unigene: 341186 Mouse Unigene: 119867 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 熱休克蛋白-90α主要在類肌細(xì)胞、間質(zhì)細(xì)胞、支持細(xì)胞核及生精細(xì)胞的胞漿表達(dá); HSP-90 alpha與腫瘤的關(guān)系密切，在許多腫瘤細(xì)胞中HSP90α表達(dá)升高.