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凝溶膠蛋白重組兔單克隆抗體

產(chǎn)品貨號：

BN42159R
中文名稱：

凝溶膠蛋白重組兔單克隆抗體
英文名稱：

Rabbit anti-Gelsolin Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42159R-50ul

50ul

￥2020.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN42159R-100ul

100ul

￥3240.00

交叉反應：Human,Mouse 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	Gelsolin
中文名稱	凝溶膠蛋白重組兔單克隆抗體
別名	Actin depolymerizing factor; ADF; AGEL; Amyloidosis Finnish type; Brevin; DKFZp313L0718; GSN; GELS_HUMAN; Actin-depolymerizing factor.
研究領域	腫瘤細胞生物免疫學
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	2G6
交叉反應	Human, Mouse,
產(chǎn)品應用	WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	80kDa
細胞定位	細胞漿分泌型蛋白
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	Recombinant human Gelsolin protein:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin, which appears to account for the difference in relative molecular weights. Function: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Subunit: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Subcellular Location: Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted. Tissue Specificity: Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. Post-translational modifications: Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. DISEASE: Amyloidosis 5 (AMYL5) [MIM:105120]: A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the villin/gelsolin family. Contains 6 gelsolin-like repeats. SWISS: P06396 Gene ID: 2934 Database links: Entrez Gene: 2934 Human Entrez Gene: 227753 Mouse Entrez Gene: 296654 Rat Omim: 137350 Human SwissProt: P06396 Human SwissProt: P13020 Mouse SwissProt: Q68FP1 Rat Unigene: 522373 Human Unigene: 21109 Mouse Unigene: 103770 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.